Page 314 - Veterinary Immunology, 10th Edition

VetBooks.ir MHC Class III Molecules

The remaining genes within the MHC are located within the class
III region (Fig. 11.7). They code for proteins with many diverse

functions. Some are important in the defense of the body such as
the genes for the complement components C4, FB, and C2 (Chapter
4). They also include genes that encode tumor necrosis factor-α
(TNF-α), several lymphotoxins, and some NK cell receptors.

FIG. 11.7 The arrangement of selected genes within the MHC
class III region. These genes all play a role in innate and adaptive
immunity. There are many other genes within this region that have
no apparent role in immunity.

314