Page 390 - Veterinary Immunology, 10th Edition
P. 390
Interferon-γ, 140
VetBooks.ir Interleukin-2, 140
Th2 Cells, 140
Interleukin-4, 140
Th17 Cells, 143
Regulatory T cells (Tregs), 143
Species Differences, 144
γ/δ T Cells, 144
Memory T Cells, 145
LEARNING OBJECTIVES
After you read this chapter, you should be able to:
• Define immunoglobulin superfamily.
• Describe the structure of the T cell antigen-binding receptor (TCR).
• Describe how the TCR recognizes ligands presented by MHC molecules on
antigen-presenting cells.
• Understand that the antigen-binding chains of the TCR connect to a complex
signal-transducing set of proteins called CD3.
• Explain why each TCR is also associated with either CD4 or CD8.
• Compare the properties and significance of CD4 and CD8, and describe the
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different roles of CD4 and CD8 T cells.
• Describe how T cells must receive additional co-stimulation from cytokines and
other molecules.
• Explain how the multiple signals sent by an antigen-presenting cell are
communicated to a T cell through an immunological synapse.
• Explain which cytokines induce Th1 cells and which cytokines are produced in
response.
• Explain how Th2 cells are induced, what they secrete, and how they promote
antibody responses.
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