Page 453 - Veterinary Immunology, 10th Edition
P. 453
APRIL is produced by monocytes, dendritic cells, T cells, and
VetBooks.ir intestinal epithelial cells. They bind to the same or related receptors
on B cells. BAFF is expressed on the cell membranes of antibody-
producing cells but can be cleaved off as a soluble cytokine. It
functions in both situations. APRIL only functions as a soluble
cytokine. They both promote B cell division and inhibit their
apoptosis. Both BAFF and APRIL are crucial survival factors for B
cells and essential for their production and differentiation.
Overexpression of BAFF results in severe autoimmune disease.
Ng LG, Mackay CR, Mackay F: The BAFF/APRIL system: life beyond B lymphocytes, Mol
Immunol 42:763-772, 2005.
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