Page 454 - Veterinary Immunology, 10th Edition

VetBooks.ir Plasma Cells

Plasma cells develop from antigen-stimulated B cells (Fig. 15.14).
Early plasma cells (plasmablasts) can be identified in the lymph

node cortex and paracortex and in the marginal zone in the spleen.
Fully developed plasma cells emigrate from these areas to the
spleen, the medulla of lymph nodes, and the bone marrow.

FIG. 15.14 B cells originate in the bone marrow and proceed
through a series of differentiation stages before becoming able to
respond to antigen. When B cells respond to antigen, they respond
by division and differentiation of their progeny into plasma cells.

Plasma cells are ovoid cells, 8 to 9 µm in diameter (Fig. 15.15).

They have a round, eccentrically placed nucleus with unevenly

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