Page 558 - Veterinary Immunology, 10th Edition

together with accessory molecules and co-stimulators. The other is
VetBooks.ir perforins, granzymes, and the CD95-CD95L signals are transmitted.
dedicated to cytotoxic mechanisms. It is through this cSMAC that

Cytotoxic T cells kill their targets through two pathways. The

perforin pathway involves the secretion of perforins and granzymes
from secretory lysosomes (Fig. 18.8). These kill cells through
intrinsic apoptotic mechanisms. The second pathway kills cells by
signaling through the CD95 death receptor. The perforin pathway is

used to destroy virus-infected cells, whereas the CD95 pathway is
mainly used to kill unwanted surplus T cells.

FIG. 18.8 The perforin pathway by which T cells kill targets.

558