Page 86 - The Manga Guide to Biochemistry
P. 86
Look at
this:
Pyruvate Acetyl-CoA
Oxaloacetate Citrate
Malate cis-Aconitate
Fumarate Isocitrate
Succinate α-ketoglutarate
Succinyl-CoA Each represents a single
carbon molecule. The carbon
Waaah! of Co A isn't shown. See page 85
My head is
spinning! for a description of Co A.
Do I have to
remember all
of this?
Kumi, you've
got vortex
eyes!
No, not quite. Just try to As you can see, after pyruvate
remember these key steps:* changes to Acetyl-CoA and then to
Pyruvate becomes Acetyl- citrate, the citrate sequentially
CoA, and oxaloacetate and transforms into various substances
acetyl condense to form the
inside the mitochondrion. then
6-carbon citrate. Later, two it finally returns to being
citrate once more.
CO2 molecules are released, Pyruvate
and Acetyl-CoA
one molecule of ATP is
produced, along with n four
molecules of NADH and o one
molecule of FADH2.
Citrate ... and
around
It's okay if you Around...
can't remember
which "-ate" word Since the reactions circle
around and around, it's
is which. called a cycle. Get it?
whew
* Each molecule of glucose is converted into two molecules of pyruvate, so two molecules of ATP, eight
molecules of NADH, and two molecules of FADH2 are created in the citric acid cycle.
