Page 136 - Medicinal Chemistry Self Assessment

3. Metabolites do not. In the case of I transformations are possible?

2.7 Drug Metabolism 125
Chlorimipramine

4. Evaluate each of the following metabolic transformations and determine which phase I metabolic
transformation has occurred.
4. Evaluate each of the which phase I metabolic transformation has occurred.

H
N C H 3 NH 2

CH 3 CH 3

CF 3 CF 3

Dexfenfluramine

Fluvoxamine

H 2 N O CO 2 H O

OH OH

Cl Cl

Baclofen

Answers

Oxidative N-dealkylation
Oxidative O-dealkylation

Oxidative deamination followed by oxidation of the resulting aldehyde to a carboxylic acid

Go to Section 1.7 [Link to section 1.7 title]
Note: References to chapters are related to Chapter 8 in Harrold MW and Zavod RM, Basic Concepts in Medic-
inal Chemistry, American Society of Health-System Pharmacists, ©2013.