Page 6 - Medicinal Chemistry Self Assessment

TABLE OF CONTENTS

Preface ......................................................................................................................................................................................... vii
Acknowledgments ......................................................................................................................................................................... ix

PART I QUESTIONS

Section 1 General Self Assessment

1.1 Functional Group Characteristics and Roles .......................................................................................................................1
1.2 Identifying Acidic and Basic Functional Groups ..................................................................................................................7
1.3 Solving pH/pK Problems ..................................................................................................................................................11
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1.4 Salts and Solubility ...........................................................................................................................................................13
1.5 Drug Binding Interactions .................................................................................................................................................17
1.6 Stereochemistry and Drug Action .....................................................................................................................................21
1.7 Drug Metabolism ..............................................................................................................................................................23

Section 2 Whole Molecule Drug Evaluation

1.8 Aliskiren ...........................................................................................................................................................................27
1.9 Aripiprazole ......................................................................................................................................................................31
1.10 Cefprozil ...........................................................................................................................................................................35
1.11 Cetirizine ..........................................................................................................................................................................39
1.12 Chlorpropamide and Other Sulfonylureas ........................................................................................................................41
1.13 Dabigatran Etexilate .........................................................................................................................................................45
1.14 Fenofibrate and Gemfibrozil .............................................................................................................................................47
1.15 Fluvoxamine .....................................................................................................................................................................51
1.16 Haloperidol .......................................................................................................................................................................55
1.17 Hydrocortisone .................................................................................................................................................................57
1.18 Levothyroxine ...................................................................................................................................................................61
1.19 Lidocaine ..........................................................................................................................................................................65
1.20 Montelukast and Zafirlukast .............................................................................................................................................69
1.21 Phenobarbital and Other Barbiturates ..............................................................................................................................71
1.22 Pravastatin and Fluvastatin ..............................................................................................................................................73
1.23 Quinapril...........................................................................................................................................................................75
1.24 Rivastigmine .....................................................................................................................................................................79
1.25 Sitagliptin .........................................................................................................................................................................83
1.26 Sorafenib ..........................................................................................................................................................................87
1.27 Zanamivir and Oseltamivir ...............................................................................................................................................91

PART 2 ANSWERS

Section 3 General Self Assessment

2.1 Functional Group Characteristics and Roles .....................................................................................................................95
2.2 Identifying Acidic and Basic Functional Groups ................................................................................................................99