Page 7 - Medicinal Chemistry Self Assessment

TABLE OF CONTENTS

2.3 Solving pH/pK Problems ............................................................................................................................................... 105
a
2.4 Salts and Solubility ........................................................................................................................................................ 109
2.5 Drug Binding Interactions .............................................................................................................................................. 113
2.6 Stereochemistry and Drug Action .................................................................................................................................. 117
2.7 Drug Metabolism .......................................................................................................................................................... 123

Section 4 Whole Molecule Drug Evaluation

2.8 Aliskiren ........................................................................................................................................................................ 129
2.9 Aripiprazole ................................................................................................................................................................... 137
2.10 Cefprozil ........................................................................................................................................................................ 143
2.11 Cetirizine ....................................................................................................................................................................... 149
2.12 Chlorpropamide and Other Sulfonylureas ..................................................................................................................... 153
2.13 Dabigatran Etexilate ...................................................................................................................................................... 159
2.14 Fenofibrate and Gemfibrozil .......................................................................................................................................... 165
2.15 Fluvoxamine .................................................................................................................................................................. 169
2.16 Haloperidol .................................................................................................................................................................... 173
2.17 Hydrocortisone .............................................................................................................................................................. 177
2.18 Levothyroxine ................................................................................................................................................................ 183
2.19 Lidocaine ....................................................................................................................................................................... 189
2.20 Montelukast and Zafirlukast .......................................................................................................................................... 193
2.21 Phenobarbital and Other Barbiturates ........................................................................................................................... 199
2.22 Pravastatin and Fluvastatin ........................................................................................................................................... 205
2.23 Quinapril........................................................................................................................................................................ 211
2.24 Rivastigmine .................................................................................................................................................................. 217
2.25 Sitagliptin ...................................................................................................................................................................... 223
2.26 Sorafenib ....................................................................................................................................................................... 227
2.27 Zanamivir and Oseltamivir ............................................................................................................................................ 233

INDEX .................................................................................................................................................................................... 239