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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

The most widely used drugs that contain anthracene derivatives are :

1- Senna Leaves and Pods.
2- Cascara Bark: Contains: cascarosides A, B, C and D
3- Frangula Bark: It contains the glycosides frangulin and glucofrangulin.
4- Aloes: It contains the C-glycosides mainly barbaloin. The C-linked glucose at C-
10 protect anthrones from oxidation.

5- Rhubarb rhizome: The presence of tannins in rhubarb makes the drug
constipating. So, in small doses, rhubarb exerts no purgative action but acts only
as intestinal astringent, but large doses cause purgation.

Warning:

Contra indicated in pregnancy and lactation

Prolonged use induces hypokalemia, potentiate the action of cardiac glycosides

4- Flavonoid Glycosides

Flavonoidal compounds are considered as the largest group of naturally occurring phenols.

Flavonoids also constitute the majority of the yellow colored plant pigments .

They are all derived from 2-phenyl-benzopyran (Flavan).

They are all derived from 2-phenyl-benzopyran (Flavan) and classified: according to the
oxidation level, and/or the oxygenation of the central pyran ring, into:

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