Page 161 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

2. Flavonol Glycosides Ex.: Rutin - Quercetrin

These two glycosides are of wide distribution in many plant genera.

OH Quercetin : R = H

HO O Quercetrin : R = rhamnosyl
OH
Rutin : R = rhamno-glucosyl

(rutinosyl)
OR
O
HO

• Rutin is the 3-rhamnoglucoside of the genin quercetin.

• It gives on hydrolysis the aglycone (quercetin) and one molecule of glucose, and
one molecule of rhamnose.

• The glycoside quercetrin, is quercetin, 3-O-rhamnoside.

• The disaccharide moiety of rutin (rhamno-glucose) is known as rutinose; which
is of common occurrence in glycosides of family rutaceae.

• Quercetrin is obtained from Quercus tinctoria.

The aglycone quercetin occurs in free state in bearberry leaves (Uva Ursi) and contributes to the
diuretic action of leaves.

Uses:

Rutin decrease the capillary fragility (increase tensile strength of capillary walls)

and reduce capillary permeability induced by histamine or by tissue injury,

so they are used in certain disease-condition to reduce capillary bleeding.

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