Page 219 - PG 504-theoretical notes-phyto-1-2024-2025..

Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

5- Apiole (Parsely camphor)

• Occurrence: in oil of parsley seed سنودقب and “Apium graveolens”
(Umbelliferae) سفرك
• Isolation: by fractional distillation then cooling
• Characters: colourless needles with faint odour of parsley
• Identification: On oxidation with KMnO4 gives apiolic acid (definite m.p. 173
ºC)
• Uses: Diuretic O O
H 3 CO O H 3 CO O
KMnO 4
OCH 3 COOH OCH 3

Apiole Apiolic acid

O
H 3 CO O

6- Dillapiole

• Dillapiole is a colorless oil. H 3 CO

• obtained from dill oil by fractional distillation.

• Dillapiole possesses a chemical charaterstics similar to those of apiol and
myristicin.

• It possesses hypolipidemic and insect repellant activity and could be used as
a lactagouge.
• Apiole and dillapiole possess mild CNS activity.

• Apiole prevent the calculi formation in kidney while dill apiole proctect
from gall bladder stones formation.

• N.B. Dill, citronella, anise, fennel, artmesia and chinchilla oils are insect repellant
and could be used in insect repellant mats
III- Terpene Oxides

1- 1,4-Cineol

It is isolated from oil of cubeb by fractional distillation.
O
Quantification and qualification of 1,4-Cineol by GC-MS and HPLC.
Estimation
:

Cineole

200