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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

• Thymoquinone possesses hepatoprotctive activity comparable with
Silymarin and inhibits leucotrienes and thromboxane synthesis which
could help in treatment of cough.
• Thymoquinone is antioxidant

3- Eugenol

OH
Occurrence: in clove oil
OCH 3

Isolation: by 5% KOH method.

Characters:

Oily liquid with clove-like odour & burning spicy taste.

It gives a blue color with FeCl3. Eugenol

K-eugenate is a needle shape crystals formed by addition KOH to eugenol in microscale.
(Microcrystallization Test)

Heating eugenol with KOH isomerise it to isoeuginol

Uses:

1. Local anaethetic & antiseptic in toothache remedies
2. combined with zinc oxide to form zinc oxide eugenol which has applications in
dentistry
3. Spice & flavouring agent
4. Potential hypocholesterolemic agent.
5. Synthesis of vanillin (not practical)

OH OK OAc OAc OH
OCH 3 OCH 3 OCH 3 OCH 3 OCH 3

alkai Ac (O) OH

Vanillin
Eugenol CHO CHO

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