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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

4) To mask disagreeable tastes.

Having 1 ➔ 2 linkage, Semi-synthetic: e.g., Sucralfate

1) Sucralfate

• Chemically, it is a complex of the disaccharide sugar, sucrose, combined with

sulfate and aluminum.

• Sucralfate is the aluminum hydroxide complex of sucrose sulfate.

• Chemical name of sucralfate is: α-D-Glucopyranoside-β-D-fructofuranosyl-

octakis-(hydrogen sulfate) aluminum complex. Its structural formula is:

• In acidic solutions (e.g., gastric acid) it forms a thick paste with a strong

negative charge.

• Properties:

• It is white powder, insoluble in water and most organic solvents, soluble in

acids and alkalies

Pharmacolgical effects:

• It is minimally absorbed into the body, and its actions are entirely on the lining

of the stomach and duodenum as it can form gel-like webbing over ulcerated or

eroded tissues serving as a sort of a bandage. It is effective in the upper GI tract:

stomach, duodenum, and possible esophagus.

• The following actions are thought to be important for its beneficial effects:

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