Page 55 - Practical Technology 2025

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Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)

3. Lubricant can affect the tablet hardness when used in too high concentration or mixed
for too long period. The lubricant will coat the granules and interfere with tablet

bonding.

4. Larger tablets require a greater force to cause fractures (harder) than small tablets.

Limits:

• Oral tablets normally have a hardness of 4 - 10 kg.

• Hypodermic and chewable tablets softer which have a hardness of 3 kg.
• Sustained release tablets are much harder which have a hardness of 11 - 20 kg.

Rules:

Deviation = Hardness of each tablet - Average Hardness

% Deviation = [ − ] X 100

F = mg

F= Force in Newton, m= Mass (hardness) in kg and g= Acceleration due to gravity
which is constant 9.8 N/kg

Example :
Tablet no. Force on Tablet Tablet Hardness (Kg) % Tablet Deviation
(N) M = F / g
1 110.11
2 112.6
3 112.9
4 117.9
5 117
6 117.3
7 116.4
8 114.3
9 119.7
10 116.6

Average

Conclusion

The tablets can be considered as …………………………………………………………….

…………………………………………………………………………………………………..

…………………………………………………………………………………………………..

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