Page 52 - Practical Technology 2025

nd
Clinical Pharmacy-Pharm D Level Three 2 Semester 2024/2025 Pharmaceutical Technology (PT 607)

Discussion

The average weight = ……………. mg

The percent deviation according to USP is ………………………… So, ………………….

…………………………………………………………………………………………………..

………………………………………………………………………………………………….

Causes of Weight Variation:

Causes of weight variation can be separated into:

❖ Granulation problems
❖ Mechanical problems

1- The actual weight of the tablet is determined by geometry of the die and the position of the

lower punch in the die.

2- If everything is working well mechanically, the weight can be caused to vary by poorly
flowing granules, which cause a spasmodic filling of the dies.

3- The improper mixing of the Glidant into the granulation can influence weight variation by
not allowing uniform flow.

4- If the granule particle size is too great for the die size, the dies will not be uniformly filled,

causing weight variation.
5- As the particle shape became more angular, the weight variation increased.

Let's scan the following QR code to show how the weight

uniformity test for tablets and capsules is performed.

50