Page 60 - Нефрон-4 бэлдмэлийн бөөр хамгаалах үйлдлийг судалсан дүн

Research materials and methodology: We gathered “Iris tenuifolia” roots from

Khurmen soum of Umnugovi province, “Ribes diacanthum Pall” and “Oxytropis
pseudoglandulosa Gonttsch” from ground surface of Yeroo soum of Selenge province,

Vaccinium vitis idaea L from Gunt nearby Ulaanbaatar in 2011 and prepared samples.
144 white rats of breed "Wistar'' weighing 180-250 g and 60 white mice of breed

“Balb” weighing 20-22 g which were on same diet and care in pharmacological sector
vivarium of the Institute of Pharmacology were used as experimental animals for this

research; and experiments were conducted for 4 experimental groups of healthy,

controls, "Nepron-4" of preparation and standard.
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Experimental results: At the 28 day following the creation of disorder sample by
kanamycin sulfate for the experimental animals, after treatment with "Nepron-4" of
preparation the amount of creatinine in serum were increased 1.2 times /animals of

treated animal group 0.45±0.009 and animals of control group 0.69±0.2 / which shows
that kidney tissues and tubular cells were getting damaged with effects of kanamycin

sulfate.

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The amount of urea in serum were decreased 1.14 the following 28 days after
creating disorder in the experimental animals by kanamycin sulfate and treating with

"Nepron-4"of preparation /36.1±4.6 for the animal of treated group and 42.4±3.5 for the

animals of control group/ which shows that inflammatory activity kidney glomerular and
tubular were decreasing with effect of kanamycin sulfate. At the 28 day of treatment it
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was decreased 1.17 the standart /36.1±4.6 for the animal of treated group and 42.4±3.5
for the animals of control group / decreased urea.

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The amount of residual nitrogen in serum were decreased 1.14 times at the 28 day
of creating kidney inflammation for experimental rats and after treatment with"Nepron-4"

/17.2±1.9. for the animals of treated group and 19.7±1.64 for the animals of control

group/ which shows decrease of kidney glomerular and tubular inflammation. The
residual nitrogent were decreased 1.15 times standart /17.1±2.1 for the animals of

treated group and 19.7±1.64 for the animals control group /.
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The amount of protein in serum were increased 1.04 times at 28 day of creating
kidney inflammation for experimental rats and after treatment with "Nepron-4" /5.9±0.24
for the animals of treated group and 6.13±0.17 for the animals of control group/ which

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