Page 158 - phytochemistry I - PharmD Clinical

• Indicated when the risk of digitalis intoxication is great, since it is
relatively short-acting and rapidly eliminated when compared with
digitoxin.

Digitoxin
• Cardiotonic glycoside obtained from D. purpurea, D. lanata.
• It is the most lipid-soluble of the cardiac glycosides used in
therapeutics.
• The major pharmacokinetic parameters for digitoxin include complete
oral absorption, which distinguishes it from other cardiac glycosides.
• Indicated in patients with impaired renal function.

2. Strophanthus

Strophanthus glycosides are cardiac glycosides characterized by either
an aldehydic (CHO) in S. kombe or primary alcoholic (CH2OH) group in
S. gratus at C-10.

• Strophanthus kombe contains K-strophanthoside (a trioside), K-
strophanthin B (a bioside) and cymarin (a monoside).

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