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振东产品 SOCIAL FOCUSPRODUCTS 振东学术·ZHENDONG SCIENCE
社会焦点 ZHENDONG

灯盏花素对老年脑卒中病人血清
灯盏花素对老年脑卒中病人血清
hs-CRP
hs-CRP、、TNF-TNF-αα水平及预后的影响水平及预后的影响
田 蕾，施春美，张义发
【摘要】目的：探讨灯盏花素对老年脑卒中病人血清超敏-C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）
水平及预后的影响。方法：将76例老年脑卒中病人随机分为对照组和研究组，各38例。对照组采用常规西

药治疗，研究组在对照组基础上采用灯盏花素治疗。采用乳胶免疫增强透射比浊法（LETIA）测定血清hs-
CRP水平，采用酶联免疫吸附试验（ELISA）测定血清TNF-α水平。观察并比较两组临床疗效、血清hs-CRP
及TNF-α水平美国国立卫生研究院脑卒中量表（NIHSS）、急性生理和慢性健康状况评价系统Ⅱ（APACHE
Ⅱ）评分、格拉斯哥昏迷评分量表（GCS）变化及不良反应发生情况。结果：研究组总有效率（94.74%）高于对
照组（65.79%），差异有统计学意义（P<0.05）。治疗后两组血清hs-CRP、TNF-α较治疗前降低（P<0.05），且

研究组低于对照组（P<0.05）；治疗后两组 NIHSS、APACHEⅡ评分低于治疗前，GCS 评分高于治疗前
（P<0.05），且研究组NIHSS、APACHEⅡ评分低于对照组，GCS评分高于对照组（P<0.05）。研究组药物不良
反应发生率为 5.26%，低于对照组的 21.05%，差异有统计学意义（P<0.05）。结论：灯盏花素治疗老年脑卒
中，可降低病人血清hs-CRP、TNF-α水平，进而改善预后。
【关键词】脑卒中；老年人；灯盏花素；超敏-C反应蛋白；肿瘤坏死因子-α；美国国立卫生研究院脑卒中量

表；急性生理和慢性健康状况评价系统Ⅱ；格拉斯哥昏迷评分量表
【中图分类号】R743 R255.2 【文献标识码】A

Effect of Breviscapine on Serum hs-CRP,of Breviscapine on Serum hs-CRP,
Effect
TNF-αα Levels and Prognosis of Elderly Stroke PatientsLevels and Prognosis of Elderly Stroke Patients
TNF-
Tian Lei, Shi Chunmei, Zhang Yifa
[Abstract]
[Abstract] Objective:Objective: To investigate the effect of breviscapine on serum levels of high sensitivity-C reactive protein
(hs-CRP),tumor necrosis factor-α (TNF-α) and prognosis in elderly stroke patients.MethodsMethods:76 elderly stroke pa-
tients were randomly divided into control group and study group,38 cases in each group.The control group was treat-
ed with conventional western medicine,while the study group was treated with breviscapine based on the control
group.The serum hs-CRP level was determined by latex immunoenhancement turbidimetry(LETIA) and the serum
TNF- α level was determined by enzyme linked immunosorbent assay (ELISA).The clinical efficacy,serum hs-

CRP and TNF - α levels of the two groups were observed and compared. The changes of NIHSS, APACHE II,
Glasgow Coma Scale (GCS) and adverse reactions were observed and compared.ResultsResults:The total effective rate of
the study group (94.74%) was higher than that of the control group (65.79%),with statistically significant differ-
ence (P<0.05).After treatment,the serum hs-CRP and TNF-α of the two groups were lower than before treatment

(P<0.05),and the study group was lower than the control group (P<0.05).After treatment,the NIHSS and APACHEⅡ
scores of the two groups were lower than before treatment,and GCS scores were higher than before treatment (P<0.05).

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