Page 123 - Genomic Medicine in Emerging Economies

112 CHAPTER 6: Neuropsy chiatric Genomics in Latin Americ a

Table 6.4 An Overview of Published Association Studies for Candidate
Genes and Neuropsychiatric Endophenotypes in Latin American Countries
Endophenotype Country Genes Reference
Aggressiveness Colombia MIR124-1 González-Giraldo et al.
(2015a)
Aggression in schizo- Mexico DRD4, MAOA Fresan et al. (2007)
phrenia
Arithmetical processing Colombia BDNF, COMT González-Giraldo et al. (2014)
BDNF serum levels in Brazil BDNF Zeni et al. (2016)
ADHD
Childhood adversities Mexico BDNF, SLC6A4 Cruz-Fuentes et al. (2014)
in adolescents
Daytime sleepiness Colombia COMT, SLC6A4 Ojeda et al. (2014a)
and diurnal prefer-
ence
Daytime sleepiness Colombia MAOA Ojeda et al. (2014b)
Delusions in schizo- Mexico MDR1 Tovilla-Zarate et al. (2014)
phrenia
Depressive symptoms Colombia BDNF, COMT, González-Giraldo et al.
MAOA, SLC6A3, (2015b)
SLC6A4
Disruptive behavior Brazil COMT Salatino-Oliveira et al. (2012b)
disorders in ADHD
Diurnal preference Colombia PER2, PER3 Ojeda et al. (2013)
Diurnal preference Colombia PER3 Perea et al. (2014)
Executive function and Mexico COMT Solís-Ortiz et al. (2010)
selective attention
Executive function in Colombia SLC6A3 Agudelo et al. (2015)
ADHD
Hyperactivity/inatten- Brazil DRD4 Tovo-Rodrigues et al. (2013)
tion scores in ADHD
Hyperactivity/inatten- Brazil COMT, SLC6A3 Akutagava-Martins et al.
tion scores in ADHD (2016)
Hyperactivity/impulsive Brazil CDH13 Salatino-Oliveira et al. (2015)
symptoms in ADHD
Obesity in bipolar Mexico BDNF Morales-Marin et al. (2016)
disorder
Oppositional symp- Brazil MAOA Guimaraes et al. (2009b)
toms in ADHD
Planning performance Colombia PER3 González-Giraldo et al.
(2015c)
Suicidal behavior in Mexico BDNF González-castro et al. (2015)
bipolar patients
Suicidal behavior Mexico 5HTR2A González-castro et al. (2013b)
Suicidal behavior Mexico THP2 Lopez-Narvaez et al. (2015)
Stroop test perfor- Colombia MIR137 González-Giraldo et al.
mance (2016b)
Verbal working Brazil MAP1B, NOS1 Salatino-Oliveira et al. (2016b)
memory in ADHD
Verbal working Brazil NOS1, SNAP25 Salatino-Oliveira et al. (2016a)
memory in ADHD
Visual-motor tracking Colombia BDNF González-Giraldo et al.
performance (2016c)