Page 120 - Genomic Medicine in Emerging Economies

Introduction 109

Table 6.3 An Overview of Published Association Studies for Candidate
Genes and Psychiatric Disorders in Latin American Countries
Disorder Country Genes Reference
Alcohol dependence Brazil DRD4, SLC6A3 Bau et al. (2001)
Alcohol dependence Brazil MAOA Contini et al. (2006)
and impulsive be-
haviors
Alcohol dependence Brazil HTR1B Contini et al. (2012)
Alcohol dependence Brazil DRD2, DRD4 Mota et al. (2013)
Alcohol dependence Brazil SLC6A3, DRD2 Vasconcelos et al.
(2015)
Antisocial personality Colombia SLC6A4, HTR1A, Cuartas Arias et al.
disorder HTR2C, HTR1B, (2011)
HTR2A, SL-
C18A2, SNAP25,
TPH1, COMT
Autism spectrum dis- Brazil 5-HTTLPR Longo et al., 2009
orders
Autism Argentina GABAA Sesarini et al. (2014)
Autism Argentina GABRG2, GABRA4 Sesarini et al. (2015)
Bipolar disorder Brazil ALOX12 Fridman et al. (2003)
Bipolar disorder Brazil SLC6A4 Meira-Lima et al.
(2005)
Bipolar disorder Brazil TPH2 Campos et al. (2010)
Bipolar disorder Brazil BDNF Neves et al. (2011)
Bipolar disorder with Brazil TPH2 Campos et al. (2011)
panic disorder co-
morbidity
Bipolar disorder Mexico, Gua- CACNA1C Gonzalez et al. (2013)
temala, and
Costa Rica
Bipolar disorder Mexico BDNF González-Castro
et al. (2015)
Eating disorder Mexico HTR1B Hernandez et al.
(2016)
Generalized anxiety Brazil BDNF Moreira et al. (2015)
disorder
Major depressive Brazil GNB3 Prestes et al. (2007)
disorder with alcohol
dependence
Major depressive Brazil SLC6A4 Segal et al. (2009)
disorder with suicide
attempt
Major depressive Argentina SLC6A4 Cajal et al. (2012)
disorder
Major depressive Mexico SLC6A4 Peralta-Leal et al.
disorder (2012)
Major depressive Brazil CRHR1 da Silva et al. (2016)
disorder
Late-onset depression Brazil TPH2 Pereira Pde et al.
(2011)