Page 15 - Pharmacology Mnemonics and Short Notes

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4. Synthetic and chemical substance: as sodium bicarbonate

Pharmacokinetics

Comprises Absorption, Distribution, Metabolism
(Biotransformation) and Excretion.
A  Absorption

D  Distribution
M  Metabolism
E  Excretion

Absorption

Absorption is defined as the passage of a drug from the site of
administration into the blood stream.

 Most drugs are absorbed (crosses cell membrane) by Passive

diffusion (along concentration gradient with no carrier or energy).
Factors That Modify Drug Absorption
1) Factors related to the drug:
a. Lipid solubility
The higher the lipid solubility of the drug the higher the rate

of drug absorption.
b. Degree of drug ionization

The greater the ionization, the lesser the absorption.
C. pH of the medium
Ionization depends on pH of absorbing media
Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman