Page 168 - Pharmacology Mnemonics and Short Notes

160

 Drugs effective at lowering VLDL and rising HDL cholesterol 
Fibric acid derivatives, Niacin and marine Omega 3 derivatives.

Fibrates  Gemfibrozil and fenofibrate

Are ligands for PPAR alpha (peroxisome proliferator activated receptor
alpha)  regulate transcription of genes involved in Lipid metabolism 

Increase synthesis of Lipoprotein lipase  associated in capillary
endothelial cells  enhanced clearance of Tg rich lipoproteins.

Uses

 Hypertriglyceridemia

 Low HDL cholesterol

Resins

Also called bile acid binding resins

Colestipol and cholestyramine  are large non-absorbable polymers that

bind to bile acids and similar steroids in intestine and prevent their
absorption  prevent recycling of bile acids  Divert hepatic cholesterol
to Bile acid synthesis resulting in decrease in cholesterol in triglyceride

regulatory pool.

 Resins  modest reduction of LDL cholesterol
Contents  No effect on HDL and Triglycerides

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman