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18. NSAIDS and drugs used in

treatment of Rheumatoid

Arthritis and Gout

NSAIDs

Non-steroidal anti-inflammatory drugs

Mechanism

Inhibit COX (Cyclooxygenase enzyme)  decrease prostaglandin and

thromboxane synthesis

COX 1 in non-inflammatory cells  normal physiological cells

COX 2 in inflammatory cells, activated lymphocytes and poly
morphoneuclear cells.

Effects

 Anti-inflammatory effect  decrease synthesis of arachidonic acid
derivatives (important mediators of inflammation)  reduce

manifestations of inflammation and have no effect on underlying
tissue and immunological reactions

 Antipyretic effect  supress prostaglandin synthesis in CNS 

reduces fever

 Analgesic effect Reduced production of prostaglandins in injured
tissues

Contents Classification

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman