Page 174 - Pharmacology Mnemonics and Short Notes

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TXA 2 increases platelet aggregation (coagulant effect).

PGI 2  decreases platelet aggregation (anticoagulant effect).

 Aspirin conc below 100mg/dl  only ThA 2 is inhibited and there is
only anticoagulant effects that last upto 300 mg/dl

 TXA 2 is inhibited PGI 2 is also inhibited so anticoagulant effect is
cancelled by coagulant effect and there will be no anti-coagulant

effect.

Adverse effects

Non selective NSAIDs

o GIT disturbances

o Renal damage

COX2 Inhibitors

o Reduced GIT damage

o Same risk or renal damage

o Increase risks of Myocardial infarction and stroke  have

more effect on PGI 2 synthesis than on TXA 2 synthesis 
increased risks of thrombosis

Aspirin and Acetaminophen

Aspirin Acetaminophen (peracitamole)
Analgesic yes

Antipyretic Yes
anti-inflammatory Not
Irreversible non selective COX Weak inhibitor of COX 1 and COX 2
inhibitor (lack anti-inflammatory)

COX 3 (in CNS) inhibitors
Anticoagulant Not

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Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman