Page 208 - Pharmacology Mnemonics and Short Notes

200

Ethanol.

 Used as antidote in methanol and ethylene glycol poisoning.

Methanol poisoning.

 Leads toxic level of formate  visual disturbances, coma and
seizures

 Death due to respiratory failure

 Fomipizol used in treatment of methanol and ethylene glycol
poisoning

 Inhibit alcohol dehydrogenase Fomipizol used in treatment of
methanol and

o Inhibit the formation of toxic metabolites (formaldehyde and
formate)

 Fomipizol  F  formaldehyde and formate

Ethylene glycol poisoning.

 Toxic aldehydes and oxalates  kidney damage and severe acidosis

Treatment of Acute ethanol withdrawal.

1) Benzodiazepines

 If Liver is working fine Long acting  diazepam

 If liver is abnormalDrugs metabolized outside the liver are used

o Lorazepam is used (outside the liver * From benzodiazepines)

 Use  prevention and treatment of acute ethanol withdrawal

syndrome

2) Thiamine (B 12)

 Coenzyme required for thiamine phosphatase
Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman