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 Use  to prevent Wernicke korsakoff’s syndrome

Drugs used in treatment of chronic alcoholism.

1) Opioid receptor antagonist

 Naltrexone used  non-selective competitive antagonist of opioid
receptors

o Reduce risks of relapse

2) Enzyme inhibitors

 Disulfiram  inhibit aldehyde dehydrogenase  accumulation of

acetaldehyde  increase acetaldehyde major cause of hangover

 Prevention of relapse in individuals with alcohol disorders

 Symptoms

Symptoms include flushing of the skin, accelerated heart rate,
shortness of breath, nausea, vomiting, throbbing headache, visual
disturbance, mental confusion, postural syncope, and circulatory
collapse.

3) Others

 Acamprostate  block NMDA receptor

o Reduce risks of relapse

Treatment of methanol poisoning

 Maintenance of vitals

 Administration of thiamine (for thiamine deficiency)

 Electrolyte (for electrolyte imbalance)

 Treatment of alcohol withdrawal syndrome  by benzodiazepines

 Treatment of alcoholism  by Disulfiram
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Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman