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31. Corticosteroids and

antagonists

Members and Classification

Corticosteroids

agonists antagonists

Glucocorticoids Mineralcorticoids Receptor antagonist Syntheisis inhibitor

Glucocorticoid Mineralocorticoid
Prednisone Fludrocortisone Ketoconazole
antagonist antagonist

Mifepristone Spironolactone

Mechanism

Enter the cell  bind to cytosolic receptor  transport corticosteroid

into nucleus  alter gene response by binding to gene response element
 specific response is made

Organ and tissue effects
Contents  Stimulate gluconeogenesis

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman