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 Blood glucose rises

 Muscle protein is catabolized,

 Insulin secretion is stimulated

 Lipolysis and lipogenesis are stimulated  with net deposition of
fat in face, shoulder and back.

Catabolic effects

 Muscle protein catabolism

 Lymphoid CT, fat and skin wasting under the influences of high

concentration of steroids

 Can lead to osteoporosis

Immunosuppressive effects

 Inhibit cell mediated immunological functions

 Delay rejection reaction with organ transplant

Anti-inflammatory effects

 Increase neutrophils

 Decrease neutrophils, basophils and monocytes

 Migration of leukocytes is also inhibited

 Induce synthesis of an inhibitor that decrease synthesis of

Phospholipase A 2

 Decrease synthesis of inflammatory mediators

Clinical uses

1) Adrenal disorders.

 Chronic adrenal cortical insufficiency (Addison’s disease)
Mineralocorticoids are used
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Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman