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Older sulphonylureas

Tolbut and Cleopatraan old couple

Tolbut  tolbutamide

Cleopatra  chlorpropamide

Rapid acting

(Rapa + nate) + Glinide  Rapaglinide and
Nateglinide

 Rapid onset and short duration of action

Adverse effect

 Can precipitate hypoglycaemia

 Allergic reactions and weight gain

Biguinides  metformin

 Inhibit gluconeogenesis in liver and kidney

 Decrease absorption of Glucose in GIT

 Stimulation of glucose uptake in periphery

Metformin  decrease insulin production ability by increasing insulin
sensitivity

 Do not increase weight

First choice in

Overweight patients or in Diabates type II

Thialidinediones
Contents Thai rose payo (in Urdu will be Thailand k rose dalna)

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman