Page 280 - Pharmacology Mnemonics and Short Notes

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Thai  thialidinediones

Rose  Rosi + Glitazone  Rosiglitazone

Payo  pio  Pio + Glitazone  Pioglitazone

Mechanism

Activate PPAR gamma receptor  activate transcription of gene 
proteins encoded that are involved in carbohydrate and lipid metabolism.

 Increase glucose uptake in muscles and adipose

 Inhibit hepatic gluconeogenesis

Reduce both fasting and post prandial hyperglycemia and are shown to

reduce risks of diabetes in high risk patients

 PPAR  peroxisome proliferator activated receptor

Alpha Glucosidase inhibitors  Acarbose

Acarbose

Inhibit alpha glucosidase  Glucose is not formed from more complex
carbohydrates  Less absorption of carbohydrates

Alpha glucosidase

Enzyme in conversion Oligosaccharides or disaccharides 
monosaccharaides in intestinal cells

 And monosaccharaides are absorbed into blood

Comparison of type 1 and 2 diabetes

Feature Type 1 diabetes Type 2 diabetes

Onset Sudden Gradual

Age at onset Mostly in children Mostly in adults
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Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman