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37. Aminoglycosides

Members and Classification

STANG

S  Streptomycin

T  Tobramycin

A  Amikacin

N  Neomycin

G  Gentamycin

Mechanism  on 30S subunit of ribosome

Aminoglycoside  A is first letter of ABC

o Block the initiation step  by blocking the formation of
initiation complex

Other mechanisms

o Inhibit translocation

o Misreading of code on mRNA

amiNOglycosides

NO  no protein synthesis

NO  effective again Negative organisms

NO  Not used in Pregnancy

Contents NO  Neomycin oral  Neomycin use is restricted to oral use to

eliminate bowel flora) (topical can also be used)

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman