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NO  Not used alone (used in combinations with Beta lactams)

NO  Nephrotoxic and Ototoxic

Uses

 HEN Peck ( see from cephalosporins)

 Streptomycin combination with penicillin  effective in enterococcal

carditis , tuberculosis, plague and tularaemia

 Netilmicin  for treatment of infection resistant to other
aminoglycosides

Resistance

o Streptococcus pneumonia and enterococci  Resistant due to
failure of drug to penetrate the cell

o Primary mechanism  Plasmid mediated formation of

inactivating enzymes  Group transferases that catalyse the
acetylation of amine functions and transfer of phosphoryl or
adenylyl group to oxygen atoms of Hydroxyl groups on
aminoglycosides

 Group transferase produced by enterococci  resistant to
gentamycin and toberamycin but not to streptomycin

Adverse effect

 Nephrotoxic

 Ototoxic

 Neuromuscular blockage

 Skin reactions

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman