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38. Sulphonamides,

Trimethoprim and

Fluoroquinolones

Sulphonamides and trimethoprim  interfere folic acid synthesis

Fluoroquinolones  inhibit microbial nucleic acid metabolism

Sulphonamides

Chemical nucleus resemble PABA (P amino benzoic acid)

 Less soluble in acidic urine

Trimethoprim

Structure similar to folic acid

 Weak bases and are trapped in urine

Reisistence

Sulphonamides  Decrease affinity of enzyme for drug + Decrease

accumilation of drug

Trimethoprim  Decrease affinity of enzyme for drug

Mechanism

Contents

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman