Page 317 - Pharmacology Mnemonics and Short Notes

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One is also called uni  so they are used in urinary tract infections

Generation 2  ciprofloxacin and Ofloxacin

Use against

Gram (+) yes

Gram (-) no

 Used in atypical pnemonia (mycoplausma pnemonia)

Genration 3 and 4  gemifloxacin, levofloxacin and moxifloxacin

Less active than generation 2 and have greater activity against gram (+)

cocci

Effective against

 Strep pneumonia aureus

 Methicillin resistant staphylococci

 Also called respiratory fluoroquinolones

Pharmakinetics

Norfloxacin Nor Not  Donot achieve adequate plasma level in most
of infections

Moxifloxacin  Eliminate also by bile Given in case of renal impairment

Mechanism

Queen on top

Fluoroquinolones  inhibit topoisomerase

 Topoisomerase II  in gram (-) (negative can be drawn between
two dots)

 Topoisomerase IV  gram (+) (positive can be drawn between four

dots)
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Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman