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Topoisomerase II  also called DNA guyrase

DNA guyrase causes relaxation of supercoiled DNA during replication

and duplication (This step is inhibited by Fluoroquinolones)

 Inhibition of Topoisomerase causes death of bacteria

Post antibiotic effect

Fluoroquinolones and aminoglycosides show post antibiotic effects 
Growthy is inhibited even after the plasma concentration of Drug is fall

below Minimum inhibitory concentration

Resistance

 Efflux pumps  Decrease intracellular accumulations

 Change in structure of porins  in gram (-) organisms

 Change in sensitivity to target enzyme via point mutations

Clinical uses

Fluorquinolone surg

S  Skin infections

U  Urogenetal tract infections

R  Respiratory tract infections

G  GIT infections
Examples

PEcK infections

P  Pseudomonas auregenosa

E  enterobacter and E.coli

K  Klebsella pneumonia

 Should not use them unless no other safe drug is available to avoid

development of resistance
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Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman