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Resistance

Kat G gene  encodes the catalase  required for bioactivation of drug

 This Gene is deleted to develop resistance

INH-A Gene  encodes the target enzymes

 This Gene is deleted to develop resistance

Pharmacokinetics

Drug  penetrate inside the cell to act on intracellular mycobacteria

Clinical uses

 Prophylaxis of Tuberculosis

 Most important Drug in Tuberculosis regimes

 Given to persons in contact with diseased person

Toxicity

Jim Loves haseena

J  jaundice

I  Insomnia

M  inhibit metabolism of Drugs in liver

Loves  Abnormal Liver function Test

Haseena  Hepatotoxic

Hepatitis

Hemolysis in G6P deficient persons

Rifampicin

Derivative of Rifamycin

Contents Mechanism

Rifampicin  R  RNA  inhibit RNA polymerase

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman