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Flu  Flu + conazole  Fluconazole

Mechanism

Azoles are pzoles

Azoles  inhibit cty p450  disrupt synthesis of ergosterol

 P450 enzyme  produces 14 alpha demethylation of lanosterol
that is converted into ergosterol component of fungal cell
membrane

Clinical Uses

For all members

 Systemic mycosis

 Conazole  candidiasis

Ketoconazole

 Ket  Cut  cutaneous  mucocutaneous candidiasis

 Systemic mycosis as other azoles
Contents Fluconazole

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman