Page 328 - Pharmacology Mnemonics and Short Notes

320

Terbinafine

To remember this

Time square

Time  terbinafine

Square  inhibit squalene epoxide

 Time duration  terbinafine is used in dermatophytosis

Toxicity

 Terbinafine and Grisofulvin  both accumulates in Keratin

 Terbinafine  Taste disturbances

 Others  GIT upset and headache

Polyenes Amphotericin B

Used in systemic fungal infections

Mechanism

amphoTERIcin  Amphotericin tearing cell membranes of Fungi

 Amphotericin  produces holes in fungal cell membrane

Bind with ergosterol  form transmembrane channels that leads to

movement of ions (Na, K and Cl)  leads to cell death

Clinical Uses

ABCD

A  Aspergillus infection

B  Blastomycosis infection

C  Candida albicans infection
Contents D  Dermatophytosis

Pharmacology Mnemonics and Short Notes By Muhammad Ramzan Ul Rehman