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Klingeborn et al.                                                                  Page 44















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                               Figure 5. Exosomal proteins highly co-enriched with the exosome-specific marker Syntenin-1,
                               differ markedly between apically and basolaterally released exosomes in a polarized RPE cell
                               culture model
                               Note that in these highly stringent exosome-specific proteome datasets, only 12 proteins are
                               released in exosomes from both sides, emphasizing the exceptional directionality in EV
                               release from polarized RPE monolayers (Klingeborn et al., 2017). Permission pending.









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                                  Prog Retin Eye Res. Author manuscript; available in PMC 2018 July 01.
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