Page 25 - FAR 222 Laboratory Manual V2 2019

FAR 222/3 Dosage Form II Semester 1/ 2019-2020

Exercise 3.4 (Replace with Extemporaneous Exercise)
Potassium sulphate 20 mg/kg/L
Magnesium chloride 160 mg/kg/L IV 50 mL/hr over 24 hr
Magnesium sulphate 190 mg/kg/L

Mitte isotonic infusion
50 kg
Question: Is this preparation iso-osmotic with blood plasma? Support your answer with calculation.

MW ∆ %w/ mmol/ g/550m
Salts mg/L
(mg/mmol) T/°C v L L
Potassium sulphate K2SO4 172 0.44 1000 0.1 5.81 0.55
Magnesium Cl MgCl2.6H2O 203 0.45 8000 0.8 39.41 4.4
Magnesium 0.094 38.62 5.23
sulphate MgSO4.7H2O 246 9500 0.95

Anhydrous dextrose 0.101 2640 0.26 1.45
4

-
2+
mmol/L K Mg Cl SO4
+
2-
K2SO4 11.63 5.82
MgCl2.6H2O 39.41 78.82
Mg SO4.7H2O 38.62 38.62
Total 11.63 78.03 78.82 44.43
89.65 123.25

2+
-
2-
+
mEq/L K Mg Cl SO4
K2SO4 11.63 11.63
MgCl2.6H2O 78.82 78.82
Mg SO4.7H2O 77.24 77.24
Total 11.63 156.05 78.82 88.86
167.68 167.68

0.52 − 0.52 − (0.1 × 0.44 + 0.8 × 0.45 + 0.95 × 0.094)
= = = 0.264% ≠
0.101

Method
1. Weigh all salts *MWQ Label
2. Dissolve the ingredients above 500 mL
separately and then mix. INTRAVENOUS INFUSION
3. Add water qs to 550 mL Potassium ion 11.63 mmol/L (11.63 mEq/L)
78.03 mmol/L (156.05 mEq/L)
Magnesium ion
4. Filter the solution using sintered glass Chloride ion 78.82 mmol/L (78.82 mEq/L)
filter no 3. Sulphate ion 44.43 mmol/L (88.86 mEq/L)
5. Check the particle using Allan viewer. Anhydrous dextrose 2.64 g/L
as
6. Transfer 500 mL solution into infusion Potassium sulphate 0.10%w/v
bottle Magnesium chloride 0.80 %w/v
7. Sterilise the preparation by autoclaving Magnesium sulphate 0.95 %w/v
at temperature: 121 - 123°C, pressure: Anhydrous dextrose 0.26 %w/v
2
1.05 kgf/cm ,15 minutes For intravenous infusion as directed by the physician
Do not use if solid particles are present
Store below 25°C
To be used on one occasion only and any remaining
solution discarded
Do not use if seal or over cap is opened or removed.
Date of sterilisation:
Expiry date: 2 years
BN:
Name of patient: Date of dispensing:
Keep out of Reach of Children

SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG

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