Page 21 - FAR 222 Laboratory Manual V2 2019
P. 21
FAR 222/3 Dosage Form II Semester 1/ 2019-2020
Exercise 2.4
Chloroquine IV 250 mg d.d. × 5/7
40 mL
Chloroquine 40 mg/mL 1.6 g
Chloroquine sulphate 53.33 mg/mL 2.13 g
Chlorocresol 0.1 %w/v 20 mL (Stock 0.2 %w/v)
Water for injection qs ad 40 mL
0.75 g C (MW 321.94) = 1g CS (MW 436) [sulfate & water = 96.06 + 18]
Ratio: CS/C = 1.333
Method
1. Weigh all solids
2. Measure chlorocresol 20 mL (stock 0.02%w/v)
3. Dissolve CS in water
4. Add chlorocresol 20 mL and mix the solution
5. Add water to 40 mL
6. Filter the solution using sintered glass filter no 3
7. Check the solution using Allen viewer
8. Sterilise the solution by heating in an autoclave or filtration by aseptic technique.
Label
20 mL
CHLOROQUINE SULPHATE INJECTION B.P.
40 mg in 1 mL as chloroquine base
(Containing 53.33 mg in 1 mL as chloroquine sulphate)
Bactericide: Chlorocresol 0.1 %w/v
For intravenous injection
Protect from light
Store at room temperature
Date of sterilisation:
Expiry date: 2 years
BN:
Name of patient: Date of dispensing:
Keep out of Reach of Children
SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG
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