Page 16 - FAR 222 Laboratory Manual V2 2019

FAR 222/3 Dosage Form II Semester 1/ 2019-2020

Exercise 1.4
Potassium ion 24 mmol/L
Sodium ion 16 mmol/L IV 150 mL/hr over 24 hr × 5/7
phosphate ion 8 mmol/L
Sulphate ion 12 mmol/L
Anhydrous dextrose q.s.
mitte isotonic infusion with potassium sulphate and sodium phosphate

+
mmol/L Na K PO4 SO4 MW Mg/L mg/550 g/L %w/v ∆
+
2-
2-
mL T/°C
16 24 8 12
K2SO4 24 12 174 12X174= 1575 2.9 0.29 0.44
2864
Na2PO4 16 8 358 8X358= 2064 1135 2.1 0.21 0.127
Anh. Dext. 21.4 g 38.9 3.89 0.101
mmol/L 40 20
mmol/L
mEq/L 16 24 16 24

0.52 − 0.52 − (0.29 × 0.44 + 0.127 × 0.21)
= =
0.101
= 3.89% ℎ. .

METHOD
Prepare for 550 mL 500 mL
1. Weigh all salts INTRAVENOUS INFUSION
2. Dissolve the ingredients above separately and Sodium ion 16 mmol/L (16 mEq/L)
then mix. Potassium ion 24 mmol/L (24 mEq/L)
3. Add water qs to 550 mL Sulphate ion 12 mmol/L (16 mEq/L)
8 mmol/L (24 mEq/L)
Phosphate ion
4. Filter the solution using sintered glass filter no Anh.dextrose 38.9 g/L
3. as
5. Check the particle using Allan viewer. Potassium sulphate 0.29%w/v
6. Transfer 500 mL solution into infusion bottle Sodium phosphate 0.21 %w/v
7. Sterilise the preparation by autoclaving at Anh.dextrose 3.89 %w/v
temperature: 121 - 123°C, pressure: 1.05
2
kgf/cm ,15 minutes For intravenous infusion as directed by the
8. Label the preparation. physician
Do not use if solid particles are present
Store below 25°C
To be used on one occasion only and any
remaining solution discarded
Do not use if seal or over cap is opened or
removed.
Date of sterilisation:
Expiry date: 2 years
BN:
Name of patient: Date of dispensing:

Keep out of Reach of Children

SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG

11