Page 15 - FAR 222 Laboratory Manual V2 2019

FAR 222/3 Dosage Form II Semester 1/ 2019-2020

Exercise 1.3 (Do until interaction then throw away)
Sodium ion 56 mEq/500 mL
Calcium ion 34 mEq/500 mL
Bicarbonate ion 12 mEq/500 mL IV 50 mL/hr over 24 hr × 3/7
Acetate ion 44 mEq/500 mL
Chloride ion 34 mEq/500 mL
mitte infusion with sodium bicarbonate, sodium acetate and calcium chloride

2+
-
Incompatibility between Ca and HCO3 → precipitation of CaCO3
+
The injection cannot be used. The Ca or HCO3 ion should be taken out and replace with Na or
2+
-
-
Cl . But, do not change the prescription. Observe CaCO3 precipitate in the solution. DO NOT filter
the solution, so prepare 500 mL. Send the preparation for sterilisation.

+
mEq/500 mL Na Ca Ac Cl - HCO3 ∆ T/°C
-
-
2+
56 34 44 34 12
CH3COONa.3H2O 44 44 0.267
NaHCO3 12 12 0.38
CaCl2.2H2O 34 34 0.298
mEq/500 mL 90 90
mEq/L 112 68 88 68 24
mmol/L 112 34 88 68 24

-
-
mmol/500 mL Na Ca Ac Cl HCO3 MW mg/500 mL g/550 g/L %w/v
-
2+
+
mL
56 17 44 34 12
NaAc 44 44 358 44X136= 5984 6.6 12 1.2
NaHCO3 12 12 84 12X84= 1008 1.1 2 0.2
CaCl2.2H2O 17 34 147 17X147= 2499 2.75 5 0.5
mmol/500 mL 73 90
mmol/L 112 34 88 68 24

0.52 − 0.52 − (1.2 × 0.267 + 0.2 × 0.38)
= = = 0.415% 2 ≠
0.298

METHOD
DO NOT FILTER THE SOLUTION 500 mL
Prepare for 550 mL INTRAVENOUS INFUSION
1. Weigh all salts. Sodium ion 112 mmol/L (112 mEq/L)
2. Dissolve the salts separately Calcium ion 34 mmol/L (68 mEq/L)
Acetate ion 88 mmol/L (88 mEq/L)
3. Mix the solutions Chloride ion 68 mmol/L (68 mEq/L)
4. Add water for injection to 550 mL. Bicarbonate ion 24 mmol/L (24 mEq/L)
5. Transfer 500 mL the solution into infusion as
bottle. Sodium acetate 1.2 %w/v
6. Close the bottle Sodium bicarbonate 0.2 %w/v
7. Sterilise the solution by autoclaving at Calcium chloride 0.5 %w/v
Temperature 121–123 °C; Pressure 1.05
2
kgf/cm ; Time for 15 minutes For intravenous infusion as directed by the physician
Do not use if solid particles are present
8. Label the preparation. Store below 25°C
To be used on one occasion only and any remaining
solution discarded
Do not use if seal or over cap is opened or removed.
Date of sterilisation:
Expiry date: 2 years
BN:
Name of patient: Date of dispensing:
Keep out of Reach of Children

SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG

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