Page 17 - FAR 222 Laboratory Manual V2 2019

FAR 222/3 Dosage Form II Semester 1/ 2019-2020

Exercise 2.1 (No need to do)
Distilled Witch Hazel B.P.C. 1973 13 %v/v
Borax q.s.
Boric acid 0.3 %w/v
Benzalkonium chloride q.s.
Distilled water q.s. ad 100 mL
ft. isotonic collyr.
sig. ut. dict.

Distilled Witch Hazel B.P.C. 1973 = Hamamelis Virginiana (density= 1.03g/mL)

Amt 100 mL ∆ T/°C
Distilled Witch Hazel B.P.C. 13 %v/v = 13.39 13 mL 0.015
1973 %w/v
Borax q.s. 0.97%=0.97g 0.241
Boric acid 0.3 %w/v 0.3 g 0.288
Benzalkonium chloride 0.01 %w/v 50 mL (0.02% stock) -
Distilled water q.s. ad 100 mL 100 mL

METHOD
12. Tare a fluted amber bottle.
13. Weigh materials (solid).
14. Measure benzalkonium Cl 50 mL
15. Add 50 mL benzalkonium Cl to the solution and mix well.
16. Use warm water to dissolve boric acid.
17. Add boric acid solution to the solution and stir until dissolve.
18. Add water to 100 mL and mix well
19. Filter solution using sintered glass filter no 3.
20. Check particles using Allen viewer
21. Transfer the tared bottle and close the bottle
22. Sterilise the preparation by autoclaving at temp 121 - 123°C, pressure 1.05 kgf/cm and
2
time 15 min or heating with bactericide at 98 – 100 °C for 30 min

Label
100 mL
HAMAMELIS OR WITCH HAZEL EYE LOTION
5 %v/v
Bactericide: Benzalkonium chloride 0.01%w/v
To be used as directed
Protect from light
For external use only
Sterile until opened
Use with care to avoid contamination during use
Stored at room temperature
Date of sterilisation:
Expiry date: 7 days after preparation
BN:
Name of patient: Date of
dispensing:

Keep out of Reach of Children
SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG

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