Page 11 - FAR 222 Laboratory Manual V2 2019

FAR 222/3 Dosage Form II Semester 1/ 2019-2020

Exercise 1.1
Neomycin eye drops
sig. iv gtt. pro ocul. dext. o.m. × 2/12

∆ E1% NaCl Eqv
BPC formula 100 mL 30 mL
T/°C
Neomycin sulphate 0.5 g 0.15 g* 0.063 0.063/0.576= 0.109x0.5=
0.5% 0.109 0.0545%
Na acid phosphate 0.7% 0.7 g 0.21 g 0.207 0.359 0.2513%
Na phosphate 0.7% 0.7 g 0.21 g 0.127 0.220 0.154%
PMN 0.002%w/v 3 mL (0.02%
solution 0.002% stock)
EDTA 0.01% (optional) 0.01% 0.003 g* 0.132 0.229 0.00229%
0.9-0.462=
NaCl for isotonicity 0.438% 0.131g
0.438%
qs ad 100 0.462%
Distilled water 30 mL
mL NaCl Eqv
*need dilution

Eye can tolerate 0.5% to 2% NaCl. Necessary to adjust isotonicity with NaCl.

Method
1. Weigh/measure all ingredients.
2. Dilution performed accordingly for MWQ. Prepare dilution for neomycin & EDTA.
3. Add all together in measuring cylinder.
4. Top up with d.water to 30 mL. Mix well.
5. Filter using sintered glass filter grade 3.
6. Check solution using Allen viewer for any particles.
7. Transfer 10 mL of the solution into eye drops bottle using a rinsed measuring cylinder.
8. Close the bottle with closure.
9. Sterilise the preparation by Method B (aseptic filtration) or C (heating with bactericide at 98
– 100 °C for 30 min).
10. Label the preparation.

Label
10 mL
NEOMYCIN SULPHATE EYE DROPS
0.5 %w/v
Bactericide: PMN 0.002%w/v
FOUR (4) drops to be applied to the right eye every morning
For external use only
Sterile until opened
Use with care to avoid contamination during use
Stored at room temperature
Date of sterilisation:
Expiry date: 4 week after opening (C) or 2 weeks after sterilisation (B)
BN:

Name of patient: Date of dispensing:

Keep out of Reach of Children
SCHOOL OF PHARMACEUTICAL SCIENCES,
USM, PENANG

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