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Arrhythmia Panels

Arrhythmia Panel (46 genes) 4 weeks

LQTS Panel (17 genes)
LQTS is characterized by the prolongation of an individual’s QT interval on ECG in a structurally 4 weeks
normal heart.
BrS Panel (14 genes)

BrS is characterized by ST segment elevation on ECG (at leads V1-3) in a structurally 4 weeks
normal heart.

CPVT Panel (7 genes)
CPVT is characterized by myocyte calcium-ion channel dysfunction due to stress-induced 4 weeks
release of catecholamines in a structurally normal heart.

SQTS Panel (5 genes)
SQTS is characterized by shortening of the QT interval on ECG in combination with paroxysmal 4 weeks
atrial and ventricular tachyarrhythmias in a structurally normal heart.
ARVC Panel (13 genes)

ARVC is arrhythmogenic condition characterized by the replacement of normal heart cells with 4 weeks
fat or fibrotic tissue, predominantly in the right ventricle. The left ventricle may also be affected
over time.

Combined Cardiac Panel (120 genes)
For patients and families with unclear or mixed clinical presentations, we also offer a combined 4 weeks
cardiac panel that includes genes associated with both arrhythmias and cardiomyopathies.
Predicted Clinical Sensitivity of Arrhythmia Genetic Testing**

80%
50-75%
70% 45-60%
Predicted Dectection Rate (%) 50% 20-45% 15-30% 10-25% 40%
60%

40%

30%

20%

10%
0%
Arrhythmia LQTS BrS CPVT SQTS ARVC
Testing Indications
** These clinical sensitivities are based on published literature as opposed to internal data. Please note, that the
4 phenotype-specific estimates assume testing of patients with a matching clinical phenotype, while the Arrhythmia
Panel estimate assumes testing of patients with ambiguous clinical presentations.