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Materials and Nanotechnology | Progress Report 329
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corresponds to D → F transition taking place one kind of fluorescent probes, for which
0 2
around 613 nm. An important feature to be there are no equivalent organic molecules.
observed is the nonexistence of broaden bands Due to its potential in market’s application,
arising from the β-diketonate centered tran- the objective of this work was to develop
sitions, indicating that intramolecular energy luminescent materials, allowing the use
transfer from the β-diketonate ligands to the of these supermolecules of lanthanides as
Eu(III) ion is operative. markers for the detection of Sickle Cell Dis-
ease (HbS). Six luminescent markers were
Development of a low cost diagnostic kit developed based on rare earth compounds.
that use luminescent Nanobiomarkers for The main methodology used for the detec -
use in sickle cell anemia tion of HbS was fluoroimunoassay, which
is already used in investigation of enzymes,
Luminescent materials, such as the rare antibodies, cells, hormones, and so on. The
earth’s complex, can be used as markers in studied methods were applied for the di -
cytology and immunology, being also used agnosis of this disease, which has genetic
as luminescent biomarkers, once the devel- origin, very typical of the hemoglobin-pa-
opment of these nanomaterials create new thology group and considered to be a public
possibilities in many fields, particularly in health problem in Brazil (ANVISA). When
diagnostic medicine. Besides, it establishes is early detected, Sickle Cell Disease (SCD)
Figure 63. SEM of the Europium and terbium supermolecules.
