Page 5 - Annual Enteritis Prevention Program - CLOSTAT 365
P. 5

A Solution for 365 Days of
                          Necrotic Enteritis Prevention



                                            CLOSTAT   365
                                                                 TM











                                                      from Healthy
                             A  L  A  N  C  E        Isolated Spores
                            B
                                                      Chicken Gut
                          A
                          T
                         O             a  n  s
                       B  I           u  l  Cidal Action on        Anti             INTEGRITY ROBUSTNESS
                      O             a  g      Clostridium      Inflammatory
                      R            o                              Action     Phytocompound
                     C                c
                     I            s                    365 Days
                    M             u  l
                                 i  l                 of Healthy
                                 c                     Intestine
                                 a
                                 B
                                        Lactic acid    Stimulatory   Minimize Intensity
                                         forming        effect on    of Predisposing
                                         bacteria      immunity        factors









         EFFECT ON COMMENSALS                   EFFECT ON INTEGRITY                       EFFECT ON
                 & PATHOGEN                          OF INTESTINE                 PRE-DISPOSING FACTORS


                                                  12                              4
            Bacteria     Control CLOSTAT TM       10                8.7           3        3.5         2.5
                                                  sIgA positive cells  6          1
          Lactobacillus   5.96 a  7.22 b           8    6.2    7                  2

          Bifidobacteria  6.16 a  7.63 b           4                              0
                                                   2
          Clostridia      7.14 a  6.33 b           0                                   Challenged   Challenged +
                                                      Control Bc  100 Gram  200 Gram      control  Phytocompound.
                                                              Bc/Mt  Bc/Mt
                              a
          Coliforms       6.73    6.17 b                 Treatments                           Lesion score

         Competitive exclusion of Pathogen,        “Increased serum IgA           Antioxidant & Ant-inflammatory
          and bifidogenic factor secretions    secretion, which maintains the tight  properties of phyto-compound
               grows commensals                                                      reduce oxidative stress
                                              junction & integrity of intestine”
                   Ref : Animal feed science 179(2013)   Ref : Xu li, B. coagulans function  Ref : Kemin Internal Source PRE-18-00183



             COMPATIBILITY ADVANTAGE TO BENEFIT WITHOUT LOSING EFFICIENCY


                                                                             Pelleting
             Anticoccidials        Antibiotics        Organic Acids                           Water sanitizers
                                                                           Temperature

                                                                                        Ref : Kemin Internal Document 08-00074
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