Page 6 - Annual Enteritis Prevention Program - CLOSTAT 365

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FEATURES OF CLOSTAT 365

Dual Anti-clostridial activity
Ensures secretion of Lipopeptides, Bacteriocins, the anticlostridial compounds
Ref: Kemin Internal Document 08-00074 , Ref: Isolation and characterization of a antimicrobial compound from
Bacillus coagulans, Emad ABD El-moniem, animals Cells and systems 2010

Compatibility with Antimicrobials Ref: EFSA Journal 2009, 7(9):1314
Stability at high temperatures Ref: Kemin Internal Source- INF-17-00028

FEATURES Constant efficacy on C. perfringens in longer usage

C. perfringens do not develop any resistance to Bacillus subtilis PB6.
Ref: Kemin Internal Source- TPA-17-00065

Quorum Quenching effect
Suppresses the chemical communication between pathogens
Ref: Yu, Q. et al Infect immun.85, (2017)

Higher Colonization & Faster Multiplication
Being isolated from Healthy chicken gut, attaches intestinal epithelium better
& multiply better than other species.
Ref: Applied & Environmental Microbiology, Aug. 2005, Vol. 71, No. 8

TM
Broiler CLOSTAT 365 Field Trial against AGPs & other probiotics

Effect on Villi Morphometry

Villi Height (μm ) Villus Height / Crypt depth
1150
30
1100
25
1050
20
1000
950 15
900 10
850 5
910 1124 1049 993 1088 19 29 22 18 23
800 0
BMD CLOSTAT TM Probiotic A Probiotic B Probiotic C BMD CLOSTAT TM Probiotic A Probiotic B Probiotic C
365 365
Ref: Kemin Internal Source- SD-21-23273 Ref: Kemin Internal Source- SD-21-23273

BMD group CLOSTAT 365 Non specific action of Probiotic C Group
TM

Stunted Villi Long & matured Villi Profuse Inflammation
in Alternates

Ref: Kemin Internal Source- SD-21-23273